PSMA is expressed more in advanced prostate cancer, probably because they need more folate. See https://pubmed.ncbi.nlm.nih.gov/19830782/. This leads to an interesting idea: could reducing dietary folate inhibit advanced PCa? Also, possibly, earlier stage PCa may not be as sensitive to Pluvicto or its brethren...since these cells may express less PSMA.
PSMA is expressed more in advanced prostate cancer, probably because they need more folate. See https://pubmed.ncbi.nlm.nih.gov/19830782/. This leads to an interesting idea: could reducing dietary folate inhibit advanced PCa? Also, possibly, earlier stage PCa may not be as sensitive to Pluvicto or its brethren...since these cells may express less PSMA.